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So, why choose Methyl D-(-)-4-Hydroxy-Phenylglycinate? Honestly, it all boils down to quality control, not just flashy product descriptions. This compound can really support your research or pharmaceutical projects—assuming its identity, purity, and stereochemical profile match what you need. Before making any decisions, it's a good idea to check out the latest certificate of analysis, the batch number, and documented testing methods.

In real lab work, those small details can make a big difference down the line. A trustworthy supplier should give you clear info on things like appearance, assay results, moisture content, residual solvents, and impurities. For confirming purity, HPLC data is pretty useful, and for structural and stereochemical details, NMR and optical rotation measurements come in handy. Remember though, these records are helpful—they don’t replace your own testing. Think of them as a solid starting point.

Evidence really does matter here. A professional purchasing team should also pay attention to how the product’s packaged, stored, shipped, and traced. Having good documentation means you can easily compare different batches and spot any surprises. It can also save you time during method development. But, beware—don’t pick a ingredient just because the supplier sounds confident. That’s not enough. Whether the compound is suitable really depends on your final application, standards, and quality requirements.

For experienced users, Methyl D-(-)-4-Hydroxy-Phenylglycinate is often valued for its well-defined chemical profile and straightforward evaluation. Still, it’s worth taking the time to review everything carefully. Sometimes product info can be incomplete, and testing results might differ from one lab to another. A good supplier should welcome your questions and provide verifiable data—that’s part of being professional. Remember, the best choice isn’t always the cheapest; it’s the one backed by clear, transparent evidence, consistent quality, and a good understanding of its limits.

Why Choose Methyl D-(-)-4-Hydroxy-Phenylglycinate?
Table of Contents [Hide]
1 Chemical Identity and Naming of Methyl D-(-)-4-Hydroxy-Phenylglycinate
2 Molecular Structure and Key Functional Groups
3 Stereochemistry and Its Influence on Compound Properties
4 Physical and Chemical Characteristics
5 Preparation Methods and Quality Considerations
6 Applications, Benefits, and Selection Factors
7 Methyl D-(-)-4-hydroxy-phenylglycinate: Properties, Applications, and Product Selection Guide

Chemical Identity and Naming of Methyl D-(-)-4-Hydroxy-Phenylglycinate

Methyl D-(-)-4-Hydroxy-Phenylglycinate is a specific methyl ester of 4-hydroxyphenylglycine. Its commonly used systematic name is methyl 2-amino-2-(4-hydroxyphenyl)acetate. PubChem records the molecular formula as C10H13NO3 and the molecular weight as 195.22 g/mol. These figures help researchers check identity before weighing a pale crystalline sample.

The letter D and the minus sign describe stereochemical and optical-rotation information. They should not be treated as interchangeable labels. Absolute configuration must be confirmed through the supplier’s certificate, chiral analysis, or an authenticated reference standard. In practical laboratory work, HPLC retention time, NMR signals, and optical rotation provide stronger evidence than a catalog name alone. Naming can still vary between databases.

ICH Q7 emphasizes documented identity testing, traceability, and controlled analytical methods for chemical materials. Those principles matter here, even during small-scale research. A reliable specification should state assay, water content, related substances, and enantiomeric purity. I would also record the measurement temperature and solvent for optical rotation; these details are easy to omit. PubChem data are useful for initial verification, but they do not replace lot-specific testing or a qualified quality review.

Molecular Structure and Key Functional Groups

Why Choose Methyl D-(-)-4-Hydroxy-Phenylglycinate?

Methyl D-(-)-4-Hydroxy-Phenylglycinate is best understood through its molecular structure. The molecule contains an aromatic benzene ring, a para-positioned phenolic hydroxyl group, an amino group, and a methyl ester. These features create a compact framework with both polar and less-polar regions. The D configuration identifies a specific three-dimensional arrangement around the chiral carbon. Small changes matter. They can influence solubility, reactivity, and interactions with surrounding molecules.

The phenolic hydroxyl group can participate in hydrogen bonding and may affect acidity under suitable conditions. The amino group provides another hydrogen-bonding site, while its protonation state depends on the chemical environment. The methyl ester contributes a defined carbonyl center and can influence hydrolysis behavior. Together, these functional groups give the compound a useful balance of structural rigidity and chemical flexibility. Still, structure is not destiny. Actual performance depends on purity, solvent, temperature, and handling conditions.

In practical evaluation, I would examine identity, stereochemical integrity, water content, and related impurities. Spectroscopic data can help confirm the aromatic, carbonyl, and hydroxyl signals, while chromatographic testing supports purity assessment. Moisture and heat deserve attention because ester-containing compounds may not remain unchanged during poor storage. The exact behavior can vary between batches. That uncertainty should encourage careful verification rather than confident assumptions. A molecular drawing is informative, but it cannot replace measured data.

Stereochemistry and Its Influence on Compound Properties

Why Choose Methyl D-(-)-4-Hydroxy-Phenylglycinate?

Stereochemistry gives this compound its identity. Methyl D-(-)-4-Hydroxy-Phenylglycinate contains a defined chiral center near the ester group. The D descriptor indicates relative configuration, while (-) describes leftward optical rotation. These terms are related, but they are not interchangeable. Confusing them can lead to poor material selection.

That small three-dimensional difference may affect reaction behavior, crystallization, and downstream selectivity. The para-hydroxy group also changes polarity and hydrogen bonding. In a reaction flask, this can influence solubility, phase separation, and impurity removal. A supplier’s name is less important than measurable evidence. Chiral HPLC, NMR, optical rotation, and water-content testing provide a more reliable profile. Still, no single test answers every question. A reported rotation value can shift with solvent, concentration, temperature, and measurement technique.

Tips: Check the certificate of analysis against your actual method. Confirm the stereochemical assignment, not only the chemical name. Store the material in a tightly closed container, away from heat and moisture. Small handling differences matter. A careful chemist should also compare a fresh sample with an older batch before changing process conditions. This step may seem excessive, yet it can reveal unexpected drift in appearance, purity, or reaction performance.

Physical and Chemical Characteristics

Why Choose Methyl D-(-)-4-Hydroxy-Phenylglycinate?

Physical and Chemical Characteristics

Methyl D-(-)-4-hydroxy-phenylglycinate is a chiral aromatic amino acid ester. Its structure combines a phenolic hydroxyl group, an amino group, and a methyl ester. These functional groups create useful hydrogen-bonding sites and moderate polarity. In practice, the material is generally handled as a crystalline solid, although appearance can vary with purity, moisture, and storage history.

The compound is not equally soluble in every solvent. Polar organic solvents may provide better compatibility than nonpolar media, while water solubility should be confirmed experimentally. Its phenolic group can influence acidity, oxidation sensitivity, and interaction with other ingredients. The D-(-) designation describes stereochemistry and optical rotation. It does not, by itself, prove identity or purity. Melting behavior, optical rotation, chromatography, and water content should be checked against reliable specifications. A small detail matters here.

Tips: Store it in a tightly closed container, away from heat, light, and excess humidity. Use clean, dry tools during sampling. Before preparation, allow the container to reach room temperature while sealed. This reduces condensation. Record the lot, appearance, solvent, and test conditions. These simple notes improve traceability, though they cannot replace validated analytical testing. Solubility should be measured, not assumed.

Preparation Methods and Quality Considerations

Why Choose Methyl D-(-)-4-Hydroxy-Phenylglycinate?

Preparation Methods and Quality Considerations

Methyl D-(-)-4-Hydroxy-Phenylglycinate is a valuable chiral intermediate for pharmaceutical research and development. Its defined D-configuration can support more consistent downstream synthesis. Preparation commonly uses controlled esterification in methanol with an acidic catalyst. Temperature, reaction time, and solvent quality require close monitoring. Poor control may increase hydrolysis products or dark-colored impurities.

Alternative coupling methods can reduce thermal stress, but they may introduce catalyst residues and additional purification steps. Crystallization remains important. Clear crystals, consistent particle size, and low moisture improve handling during formulation development. This sounds simple. It is not always simple.

Quality testing should combine orthogonal methods. Chiral HPLC confirms enantiomeric purity, while conventional HPLC measures assay and related substances. NMR and LC-MS help verify molecular identity. Karl Fischer analysis measures water content, and gas chromatography checks residual methanol. ICH Q3C(R8) lists methanol as a Class 2 solvent with a 3,000 ppm concentration limit. ICH Q3D(R2) also establishes permitted daily exposures for elemental impurities, including lead at 5 micrograms per day for oral products. These limits guide risk assessment, not automatic product approval. A 99.5% assay result can still hide a critical chiral impurity. Batch records, validated methods, and stability data therefore matter as much as the headline purity.

Why Choose Methyl D-(-)-4-Hydroxy-Phenylglycinate?

Preparation Methods and Quality Considerations

Preparation perspective: Methyl D-(-)-4-hydroxy-phenylglycinate is commonly prepared by esterifying D-(-)-4-hydroxyphenylglycine with methanol under acid catalysis. Activated-ester or coupling-based routes can also be selected when milder conditions or tighter stereochemical control are required.

Quality perspective: The molecular-mass relationship provides a useful stoichiometric identity check: esterification increases the substrate molecular mass by the net incorporation of a methyl group, while water is formed as the condensation by-product. In practical quality control, HPLC purity, chiral HPLC or optical rotation, water content, residual solvents, NMR, and mass spectrometry should be evaluated.

Molar-mass values shown: D-(-)-4-hydroxyphenylglycine, 167.16 g/mol; methyl D-(-)-4-hydroxy-phenylglycinate, 181.19 g/mol; water, 18.015 g/mol. Stereoisomers have the same molecular mass.

Applications, Benefits, and Selection Factors

Why Choose Methyl D-(-)-4-Hydroxy-Phenylglycinate?

Methyl D-(-)-4-Hydroxy-Phenylglycinate is a chiral pharmaceutical intermediate with an ester group and a para-hydroxyl group. These functional sites support controlled synthesis routes for selected beta-lactam compounds and related research targets. Its defined D-configuration can reduce stereochemical uncertainty during process development. That matters when reaction yield, impurity control, and reproducibility must be measured together. IQVIA Institute’s 2024 Global Use of Medicines report projects global medicine spending will approach 2.3 trillion dollars by 2028. Such growth increases pressure on intermediate suppliers to provide consistent, traceable materials.

Applications depend on more than chemical identity. Buyers should review assay, enantiomeric purity, water content, residual solvents, and metal levels. HPLC data and optical rotation can help confirm each lot’s identity and stereochemical quality. ICH Q7 also emphasizes documented controls for pharmaceutical starting materials and intermediates.

Small differences matter. A slightly higher impurity profile may affect downstream crystallization, color, or reaction time. This is often missed in early purchasing decisions.

Selection should include a current certificate of analysis, validated test methods, packaging details, and storage evidence. Suppliers with documented change control are easier to audit and qualify. Experience suggests that the lowest quoted price may not represent the lowest process cost.

However, analytical specifications alone cannot guarantee perfect performance. Reaction conditions, equipment, and operator skill still influence outcomes. A practical evaluation uses pilot-scale testing before routine procurement.

Methyl D-(-)-4-hydroxy-phenylglycinate: Properties, Applications, and Product Selection Guide

Methyl D-(-)-4-hydroxy-phenylglycinate is a chiral aromatic amino-acid derivative identified by CAS No. 37763-23-8. Its molecular formula is C₉H₁₁NO₃, with a molecular weight of 181.191 g/mol and a composition of nine carbon, eleven hydrogen, one nitrogen, and three oxygen atoms. Public chemical databases, including the European Chemicals Agency (ECHA) inventory and the U.S. EPA CompTox database, list related identification records such as EC Numbers 253-657-2 and 806-897-2, DSSTox Substance ID DTXSID00958815, and Nikkaji Number J238.216D. These identifiers help purchasers verify substance identity across international documentation.

The compound is primarily considered a specialty intermediate for laboratory research, chiral synthesis, and the development of fine-chemical or pharmaceutical-related compounds. Its para-hydroxyphenyl structure and stereochemical configuration can support selective synthetic routes, although the suitability of a particular grade depends on the intended reaction and process requirements. When selecting a product, buyers should review assay, enantiomeric purity, water content, residual solvents, appearance, stability data, and batch-to-batch consistency. A complete certificate of analysis and safety data sheet should accompany each lot.

For international procurement, the listed HS Code is 2942000000, while the EC, DSSTox, and Nikkaji identifiers provide additional traceability. Buyers should also confirm packaging, storage conditions, retest period, documentation quality, and applicable import or workplace requirements. Independent testing may be appropriate when the material is used in regulated research or quality-sensitive synthesis.

Methyl D-(-)-4-hydroxy-phenylglycinate

FAQS

What is Methyl D-(-)-4-Hydroxy-Phenylglycinate?

It is a methyl ester of 4-hydroxyphenylglycine. Its systematic name is methyl 2-amino-2-(4-hydroxyphenyl)acetate. The molecular formula is C10H13NO3. Its molecular weight is 195.22 g/mol.

What functional groups does this compound contain?

The molecule contains a benzene ring and a para-positioned phenolic hydroxyl group. It also contains an amino group and a methyl ester. These groups create polar and less-polar regions. The structure is compact.

What do D and (-) mean?

The D descriptor describes a stereochemical arrangement. The minus sign describes leftward optical rotation. They are not interchangeable labels. That distinction is easy to miss.

How can researchers confirm the compound’s identity?

Researchers can compare HPLC retention time, NMR signals, and optical rotation. They should also check molecular formula and molecular weight. A pale crystalline sample still needs testing. A name alone is insufficient.

How can stereochemical purity be evaluated?

Chiral HPLC can help measure enantiomeric purity. NMR and optical rotation provide supporting evidence. A qualified reference standard may strengthen the assignment. One test rarely answers everything.

Which quality details should a specification include?

A useful specification should state assay, water content, related substances, and enantiomeric purity. It should identify analytical methods and acceptance limits. The testing records should remain traceable. I might still overlook temperature details.

What conditions may affect the compound during storage?

Heat and moisture may affect ester-containing materials. Store the compound in a tightly closed container. Keep it away from excessive heat and damp conditions. Small changes matter.

Why can batches behave differently?

Differences in purity, moisture, stereochemical integrity, or storage history may affect performance. Solvent and temperature can also change solubility or reaction behavior. Compare a fresh sample with an older batch before changing conditions. That extra check can reveal unexpected drift.

Conclusion

Methyl D-(-)-4-Hydroxy-Phenylglycinate is a chiral organic compound identified by its methyl ester group, hydroxy-substituted aromatic ring, and amino acid-derived carbon framework. Its molecular structure contains functional groups that contribute to polarity, hydrogen bonding, and chemical reactivity. The D-(-) stereochemical designation is important because molecular configuration can influence physical behavior, reaction pathways, solubility, and compatibility with other substances. Understanding its identity and stereochemistry helps users evaluate the compound more accurately for technical or research purposes.

The compound’s physical and chemical characteristics should be assessed through reliable specifications, including appearance, purity, moisture, optical rotation, and analytical profile. Preparation may involve controlled esterification and purification steps, while quality depends on raw-material control, process consistency, and suitable storage conditions. Potential applications and benefits are related to its functional groups and stereochemical properties, but selection should be based on the intended use, required purity, stability, documentation, and handling requirements. Careful evaluation supports consistent performance and responsible use.

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Jackson

Jackson

Jackson is a dedicated marketing professional at Shijiazhuang Pengnuo Technology Co., Ltd., a company established in 2020 that specializes in the research and development, production, and sales of pharmaceutical intermediates and fine chemical products. With a strong background in the chemical and......
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