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Picking the best 2,4-Diamino-6-Hydroxypyrimidine manufacturer in China isn’t just about comparing prices from catalogs. You really want a supplier who can show consistent production, provide clear technical docs, and has hands-on experience with international clients. When it comes to 2,4-Diamino-6-Hydroxypyrimidine, folks usually look at things like identity, purity, moisture content, residual solvents, and whether each batch stays the same—these details matter a lot, especially if you're heading into pharmaceutical research or other tightly regulated industries.

Try to find a manufacturer that can serve up up-to-date spec sheets, certificates of analysis, safety data sheets, and traceable batch info. Reliable companies won’t hide behind vague marketing talk—they should openly explain their quality control processes. It’s also helpful to look at their facilities’ capabilities, lab equipment, packaging standards, sample support, and how quick they are to get back to you. And don’t forget to ask if they can consistently produce the same quality over multiple orders. Little things like a sealed inner bag, clear lot numbers, and sturdy outer cartons can really save you from storage or shipping headaches.

That said, labeling someone as the “best” isn’t set in stone. Suppliers can perform differently depending on raw material lots, production schedules, staffing, or their quality management. Plus, publicly available info isn’t always complete, so doing your own verification makes sense. It’s smart to request samples, review recent documentation, and see how responsive they are before making any long-term commitments. Comparing different China-based manufacturers carefully can help cut down on surprises and make your sourcing of 2,4-Diamino-6-Hydroxypyrimidine both safer and more reliable.

China Best 2,4-Diamino-6-Hydroxypyrimidine Manufacturer?
Table of Contents [Hide]
1 What Is 2,4-Diamino-6-Hydroxypyrimidine?
2 Key Properties and Chemical Characteristics
3 Main Applications of 2,4-Diamino-6-Hydroxypyrimidine
4 How to Evaluate a Chinese Manufacturer
5 Manufacturing Standards and Quality Control
6 Product Supply, Customization, and Technical Support
7 2,4-Diamino-6-hydroxypyrimidine: Properties, Applications, and Safe Handling Guide

What Is 2,4-Diamino-6-Hydroxypyrimidine?

2,4-Diamino-6-Hydroxypyrimidine is a heterocyclic compound used mainly as a pharmaceutical and fine-chemical intermediate. Its molecular formula is C4H6N4O, with a reported molecular weight of 126.12 g/mol. PubChem lists the compound under several naming variations, including 2,4-diaminopyrimidin-6-ol and its keto tautomer. This naming difference matters during procurement and analytical testing.

The compound typically appears as a pale crystalline solid. Public chemical data sources, including PubChem and the European Chemicals Agency information portal, support checking identity, purity, and safety information before production use. Industry quality practice commonly combines HPLC, NMR, melting-point testing, and Karl Fischer moisture analysis. A reliable manufacturer should provide batch records, a current certificate of analysis, and traceable raw-material documentation. Small differences in water content can affect downstream reactions. This point is easy to underestimate.

Tips: Ask for the CAS number, molecular formula, assay method, and storage conditions. Compare chromatograms, not only headline purity. A 99% assay may still hide an unsuitable impurity profile. Request a representative sample before approving a larger order. Check packaging integrity, labeling, and transport conditions. Supplier audits are useful, but they are not perfect. Independent verification remains sensible.

Sources: PubChem Compound Summary; European Chemicals Agency substance information; OECD eChemPortal chemical data resources.

Key Properties and Chemical Characteristics

China Best 2,4-Diamino-6-Hydroxypyrimidine Manufacturer?

2,4-Diamino-6-hydroxypyrimidine is a nitrogen-rich heterocyclic compound with the molecular formula C4H6N4O. Its molecular weight is approximately 126.12 g/mol. The structure contains two amino groups and one hydroxyl group attached to a pyrimidine ring. These functional groups support hydrogen bonding and influence its polarity, crystal packing, and reactivity.

The molecule may exist in different tautomeric forms. This detail can affect analytical results and formulation behavior. It commonly appears as a pale solid, while water solubility may remain limited under neutral conditions. Solubility can change with pH, temperature, particle size, and solvent selection. The compound is not effortless.

When evaluating a China-based manufacturer, technical documentation matters as much as price. A dependable supplier should provide batch-specific assay data, impurity profiles, moisture results, and residual-solvent information. HPLC can support purity testing, while NMR, mass spectrometry, and infrared analysis help confirm identity. Manufacturing controls should address mixing uniformity, drying conditions, packaging, and traceability.

Small details matter. A practical quality review should compare the certificate of analysis with independent test results. Differences in color or flowability do not always indicate contamination, but they deserve investigation. Clear storage instructions, stable batch records, and responsive technical communication also indicate professional production. Specifications should be agreed before purchase, because “high purity” alone is not a complete quality standard.

Main Applications of 2,4-Diamino-6-Hydroxypyrimidine

2,4-Diamino-6-Hydroxypyrimidine is a valuable heterocyclic building block for pharmaceutical research and fine chemical synthesis. Its pyrimidine ring offers two amino groups and one hydroxyl group for controlled chemical modification. Researchers use it to prepare substituted pyrimidines with potential biological activity. These compounds may support studies involving enzyme inhibitors, nucleic acid analogues, and other therapeutic candidates. The exact application depends on the reaction route and the required functional groups.

It also serves as an intermediate in selected agrochemical and laboratory synthesis programs. In these processes, chemists may convert the hydroxyl group or modify the amino positions through carefully controlled reactions. Manufacturing quality matters here. Consistent assay, low moisture, controlled particle size, and reliable impurity data can improve batch performance. Traceable documentation is equally important for regulated research environments.

The practical picture is less tidy. Not every synthesis needs the same purity level. Some routes also respond strongly to water content and heating conditions. Small differences can affect yield, filtration, or final color. Experienced suppliers therefore evaluate the intended use before recommending a specification. A useful technical discussion should include reaction conditions, packaging, storage temperature, and analytical methods. This compound is not merely a catalog powder; it is a route-dependent material requiring careful handling and verification.

How to Evaluate a Chinese Manufacturer

China Best 2,4-Diamino-6-Hydroxypyrimidine Manufacturer?

How to Evaluate a Chinese Manufacturer

A reliable evaluation starts with evidence, not attractive product pages. Request the manufacturer’s legal company details, production address, quality certificates, and recent batch records. ISO’s 2022 Survey reported more than 1.2 million ISO 9001 certificates worldwide. However, certification alone does not prove strong chemical control. Ask whether the certificate covers the actual manufacturing site. Review HPLC results, NMR data, moisture, residual solvents, and heavy-metal limits. These details reveal more than a sales presentation.

Production experience matters. Ask for anonymized case histories, typical batch size, annual capacity, and retention-sample procedures. A professional supplier should explain how it manages raw-material changes, deviations, and customer complaints. Request a current SDS and a detailed COA for every shipment. Compare specifications with your intended process. A low assay limit may look acceptable, yet it can create purification costs later. I have seen evaluations focus too heavily on price. That is a costly weakness.

Tips: Arrange a video audit or an independent site inspection. Check drums, labels, weighing areas, and warehouse segregation. Confirm traceability from raw material to finished batch. Ask for a small trial batch before signing a long-term agreement. Review export documentation and applicable chemical requirements with your compliance team. One more caution: supplier data may be incomplete or outdated. Recheck it before approval.

Manufacturing Standards and Quality Control

China Best 2,4-Diamino-6-Hydroxypyrimidine Manufacturer?

A reliable manufacturer of 2,4-Diamino-6-Hydroxypyrimidine should follow documented manufacturing standards. Each batch needs clear records, from raw material receiving to final packaging. Trained technicians should control temperature, reaction time, pH, and drying conditions. These details can affect purity and product consistency. A strong quality system should include equipment calibration, process validation, change control, and traceable batch numbers. ISO 9001-based procedures can support consistency, but certification alone does not prove product quality.

Quality control should combine identity testing with purity analysis. HPLC can measure assay and related impurities, while NMR or mass spectrometry can confirm molecular identity. Moisture, residual solvents, ash, and physical appearance also require defined limits. Sampling plans should prevent results from representing only the surface of a batch. Retain samples and complete certificates of analysis improve customer confidence. In practice, no process is perfect. Unexpected variation can still occur, so deviation reviews and corrective actions must be genuine, not just paperwork.

Tips: Ask for recent batch data, test methods, specification limits, and traceability records. Check whether the supplier explains out-of-specification results clearly. Visit the facility when practical. Observe laboratory cleanliness, labeled containers, and controlled storage conditions. Do not judge a manufacturer only by a low quotation. A cheaper material may create higher testing, reformulation, or production costs later. Also, confirm that packaging protects the compound from moisture, contamination, and excessive heat during transport.

Product Supply, Customization, and Technical Support

China Best 2,4-Diamino-6-Hydroxypyrimidine Manufacturer?

Reliable supply starts with consistent quality. 2,4-Diamino-6-Hydroxypyrimidine has a molecular weight of 126.12 g/mol and requires controlled handling during synthesis and packing. A capable Chinese manufacturer should provide batch-specific HPLC results, NMR identification, moisture testing, residual-solvent data, and trace-metal results. The 2024 Deloitte Global Chemical Industry Outlook highlights supply-chain resilience as a major industry priority. That means buyers need more than a low quotation. They need stable lead times, documented raw-material controls, and realistic production capacity.

Customization should fit the application. Standard options may include different package sizes, particle profiles, purity targets, and labeling formats. Technical teams can review reaction conditions, solubility behavior, sampling plans, and storage requirements before production. A 2023 report from the International Council of Chemical Associations recorded continuing investment in process efficiency and digital quality systems across the chemical sector. For this intermediate, practical support may include a pre-shipment sample, method-transfer assistance, and rapid investigation of abnormal test results.

Small details matter. A drum label should match the certificate exactly. Custom work also needs limits. Not every requested specification is economical or technically stable, and this point is sometimes explained too late. Experienced suppliers should disclose that risk early, then propose a workable specification, pilot batch, and inspection schedule. That approach supports safer purchasing and more dependable downstream development.

2,4-Diamino-6-hydroxypyrimidine: Properties, Applications, and Safe Handling Guide

2,4-Diamino-6-hydroxypyrimidine is a nitrogen-rich pyrimidine derivative identified by CAS No. 56-06-4 and molecular formula C₄H₆N₄O. It has a molecular weight of 126.118 and contains four carbon atoms, six hydrogen atoms, four nitrogen atoms, and one oxygen atom. The compound is also listed under the alternative name 2,6-diamino-4-hydroxypyrimidine. Its heterocyclic structure and multiple amino groups make it a useful building block for laboratory research and chemical synthesis.

In professional settings, this material may be used as a research intermediate in the preparation and evaluation of pyrimidine-based compounds, including studies involving medicinal chemistry, organic synthesis, and analytical reference work. Its functional groups can support further chemical modification, making appropriate purity assessment and controlled reaction conditions important. Product documentation should include the CAS number, molecular formula, molecular weight, and HS Code 29335995 to support identification, procurement, and regulatory recordkeeping.

For safe handling, work in a well-ventilated laboratory while wearing suitable gloves, protective eyewear, and a laboratory coat. Avoid generating or inhaling dust, and prevent contact with the eyes, skin, and clothing. Store the material tightly sealed in a cool, dry, well-ventilated area, away from incompatible substances, heat, and moisture. Any spill should be collected using methods that minimize dust and disposed of according to the applicable safety data sheet and local waste-management requirements.

2,4-Diamino-6-hydroxypyrimidine

FAQS

What is 2,4-Diamino-6-Hydroxypyrimidine?

It is a nitrogen-rich heterocyclic compound with the molecular formula C4H6N4O. Its molecular weight is about 126.12 g/mol. The structure contains two amino groups and one hydroxyl group. It usually appears as a pale solid.

How does its structure affect performance?

The functional groups support hydrogen bonding and influence polarity, crystal packing, and reactivity. Different tautomeric forms may affect testing and formulation behavior. This detail is easy to overlook.

Is it highly soluble in water?

Water solubility may remain limited under neutral conditions. Solubility can change with pH, temperature, particle size, and solvent selection. Testing the actual process conditions is advisable.

What should buyers request from a manufacturer?

Request batch-specific assay data, impurity profiles, moisture results, and residual-solvent information. Also request test methods, specification limits, packaging details, and traceability records. “High purity” alone is incomplete.

Which tests help confirm identity and purity?

HPLC can measure assay and related impurities. NMR, mass spectrometry, and infrared analysis can support identity confirmation. Moisture, ash, appearance, and residual solvents also need defined limits.

What manufacturing controls are important?

Important controls include temperature, reaction time, pH, mixing, drying, and equipment calibration. A reliable system should include batch records, process validation, change control, and retain samples. Paperwork should reflect real practice.

Where is this compound commonly used?

It is used as a building block in pharmaceutical research and fine chemical synthesis. Researchers may prepare substituted pyrimidines for enzyme studies and nucleic acid analogue research. It can also support selected agrochemical and laboratory synthesis programs.

Does every application require the same specification?

No. Purity, moisture, particle size, and impurity limits depend on the reaction route. Water content or heating conditions may affect yield, filtration, and final color. The intended use should guide the specification.

How can a buyer compare suppliers fairly?

Compare recent batch data with independent test results when practical. Inspect labeled containers, laboratory cleanliness, controlled storage, and packaging protection. A low quotation may create higher testing or reformulation costs later. No supplier is perfect.

Conclusion

This article provides a practical overview of 2,4-Diamino-6-Hydroxypyrimidine, including its chemical structure, key properties, stability, solubility, and role as an important intermediate in pharmaceutical and fine chemical research. It explains how the compound is evaluated for purity, consistency, handling requirements, and suitability for different production or laboratory applications.

The guide also outlines how to assess a Chinese manufacturer by reviewing production capability, quality management systems, testing methods, documentation, and regulatory compliance. Attention is given to manufacturing standards, batch-to-batch control, packaging, supply reliability, customization options, and technical support. By considering these factors, buyers can identify a dependable supplier that offers consistent 2,4-Diamino-6-Hydroxypyrimidine quality, clear communication, flexible specifications, and professional service throughout the procurement process.

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Charlotte
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Charlotte

Charlotte

Charlotte is a dedicated marketing professional at Shijiazhuang Pengnuo Technology Co., Ltd., a company known for its expertise in the research, development, production, and sales of pharmaceutical intermediates and fine chemical products since its establishment in 2020. With a strong academic......
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